Prenatal exposure to selective serotonin reuptake inhibitors and risk of disorders of gut-brain interaction in children.

ABSTRACT: Preclinical data suggest that gestational exposure to selective serotonin reuptake inhibitors (SSRI) alter gut innervation, and delays colonic motility. In this study we investigated associations between gestational SSRI exposure and offspring disorders of gut-brain interaction (DGBI). Using population-based registries, we included all single-birth Danish children born 1997-2015 with follow-up until outcome occurrence, age 15 years, death, emigration, or December 2018. Children to mothers who continued SSRIs during pregnancy and children to mothers who discontinued SSRI use before pregnancy were compared using Cox regression. Main outcomes were the first diagnosis of a childhood DGBI (functional nausea and vomiting, functional abdominal pain disorders, functional diarrhea, and functional c

SUBMITTER: Kildegaard H 

PROVIDER: S-EPMC12434578 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature