Tough dual-network Janus hydrogel patch for universal and reversible adhesion.

ABSTRACT: Traditional hydrogel adhesives hold tremendous potential in applications of hemostasis, wound closure, and tissue regeneration. However, significant challenges exist concerning the unsatisfactory mechanical properties and indiscriminate adhesion of the hydrogel, which possibly result in unwanted postoperative adhesion of tissues. In this work, a Janus hydrogel was fabricated from naturally-derived aspartic acid, glutamic acid, and dopamine. The hydrogel accomplishes the dual-sided property modulation through the coordination of Fe³⁺, maintaining high adhesion on one side while eliminating most of the adhesion on the other, efficiently averting unintended adhesion. Remarkably, this hydrogel patch not only attained robust mechanical strength (around 410 kPa) and stability via</

SUBMITTER: Pu X 

PROVIDER: S-EPMC12434584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature