Identification of Tumor Antigens and Immune Subtypes in Hepatocellular Carcinoma From a Multiomics Perspective.

ABSTRACT:

Background

Immunotherapies including immune checkpoint inhibitors and tumor antigen based vaccines have revolutionized cancer treatment. However, immune signatures of hepatocellular carcinoma (HCC) have not been thoroughly studied from a multiomics perspective.

Aims

In this study, we aimed to identify the potential tumor antigens and immune subtyping for HCC using multiomics data.

Methods and results

The study included 159 HCC patients with genome, transcriptome, proteome, and phosphoproteome data. Two potential tumor antigens, ZNF831 and SYNE1, showed significant superior prognostic effects and positive correlations with antigen presenting cells, which provided promising candidates for the development of tumor antigen-based mRNA vaccine. A multiomics clustering using

SUBMITTER: Wang C 

PROVIDER: S-EPMC12434600 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature