Longitudinal changes in the brain-age gap in mild cognitive impairment and their relationships with neuropsychological functions and Alzheimer's disease biomarkers.

ABSTRACT:

Introduction

The discrepancy between biological and modeled brain ages-the brain-age gap (BAG)-could indicate potential neuropsychological changes. This study verified if and how longitudinal BAG changes were associated with neuropsychological functions and Alzheimer's disease-related biomarkers in individuals with mild cognitive impairment (MCI).

Methods

One hundred thirty-eight individuals with MCI and 103 healthy controls (HCs) with three rounds of magnetic resonance imaging scanning were selected from the Alzheimer's Disease Neuroimaging Initiative. We applied support vector regression on functional connectivity for modeling the brain age and further calculated the BAG.

Results

Longitudinal BAG changes were higher in participants with MCI compared to HCs. Larger B

SUBMITTER: Jin RR 

PROVIDER: S-EPMC12434607 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature