Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.

ABSTRACT:

Background

Mixed neuropathology is common in dementia, but the clinical implications for neuropsychiatric symptoms (NPSs) are not well characterized.

Methods

In a population-based post mortem study, cases with Alzheimer's disease neuropathological change (ADNC) and Lewy body disease (LBD) were identified with any comorbid neuropathology (limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy neuropathological change (LATE-NC), cerebrovascular disease, LBD, and ADNC, respectively). Post mortem interviews collected information regarding NPSs and cognition to explore associations between each co-pathology and NPSs across the whole cohort, as well as in participants without dementia.

Results

Co-existing neuropathology was frequent, even

SUBMITTER: Gibson LL 

PROVIDER: S-EPMC12434609 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature