Investigating the oxidative stress-vascular brain injury axis in mild cognitive impairment of the Alzheimer's type.

ABSTRACT:

Introduction

Oxidative stress may contribute to brain injury in the Alzheimer's disease (AD) continuum. The antioxidant glutathione (GSH) can be assessed with magnetic resonance spectroscopy (MRS). Because the relationship between GSH and vascular brain injury is unknown in the AD continuum, we address this gap in mild cognitive impairment (MCI).

Methods

3T Magnetic resonance imaging (MRI)/MRS data were obtained from 31 patients with MCI. GSH and total N-acetylaspartate (tNAA; neuroaxonal integrity marker) were measured in posterior cingulate cortex (PCC) and frontal white matter (FWM). Cerebrovascular injury was assessed using white matter hyperintensity (WMH) volume. Global and regional brain tissue integrity were assessed using normalized brain (NBV) and hippocampal volum

SUBMITTER: Detcheverry FE 

PROVIDER: S-EPMC12434610 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature