Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome.

ABSTRACT:

Introduction

Cerebrovascular disease is elevated across the Alzheimer's disease (AD) continuum in adults with Down syndrome (DS), but regional change within individuals is unknown.

Methods

Participants from the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study (n = 187) had magnetic resonance imaging (MRI) scans quantified for white matter hyperintensity (WMH) volume. Annualized WMH change was assessed across cognitive diagnostic groups defined by progression or stability between two visits (78% remained cognitively stable (CS), 6% progressed from CS to mild cognitive impairment [MCI]-DS, 5% remained MCI-DS, 6% progressed from MCI-DS to AD, 4% remained AD).

Results

Compared to those who remained CS, WMH changes, particularly in posterior regions, over time

SUBMITTER: Lao P 

PROVIDER: S-EPMC12434704 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature