Pre-infusion risk factors predict severe infectious complications of CAR T-cell therapy in pediatric and adult patients with B-ALL.

ABSTRACT:

Background

Despite the curative potential for chimeric antigen receptor (CAR) T-cells in B-cell acute lymphoblastic leukemia (B-ALL), efficacy can be limited by life-threatening adverse events such as severe infections. As immune effector cell-associated hematotoxicity and secondary immunodeficiency may be particularly profound in B-ALL, understanding pre-infusion risk of severe infection is imperative. The ALL-HEMATOTOX (ALL-HT) score is a recently validated tool designed to predict CAR-associated hematotoxicity in B-ALL, but the relationship between ALL-HT and severe infections post-infusion has not yet been comprehensively assessed.

Methods

In this multicenter, retrospective analysis, we evaluated ALL-HT and other pre-infusion variables for an association with severe infe

SUBMITTER: Culbert AA 

PROVIDER: S-EPMC12434746 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature