Developing and validating a risk prediction model for conversion to type 2 diabetes mellitus in women with a history of gestational diabetes mellitus: protocol for a population-based, data-linkage study.

ABSTRACT:

Introduction

Women with gestational diabetes mellitus (GDM) are at seven-fold to ten-fold increased risk of type 2 diabetes mellitus (T2DM) when compared with those who experience a normoglycaemic pregnancy, and the cumulative incidence increases with the time of follow-up post birth. This protocol outlines the development and validation of a risk prediction model assessing the 5-year and 10-year risk of T2DM in women with a prior GDM diagnosis.

Methods and analysis

Data from all birth mothers and registered births in Victoria and South Australia, retrospectively linked to national diabetes data and pathology laboratory data from 2008 to 2021, will be used for model development and validation of GDM to T2DM conversion. Candidate predictors will be selected considering existi

SUBMITTER: Versace V 

PROVIDER: S-EPMC12434774 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature