The effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment.

ABSTRACT:

Introduction

Previous studies have yielded conflicting results regarding the effect of probiotics on prediabetes. To address this, we did an updated systematic review and meta-analysis of existing studies to evaluate the effects of probiotics on prediabetes.

Methods

We conducted a thorough search for pertinent trials on the impact of probiotic supplementation on prediabetes using various databases such as PubMed, Medline, and Google Scholar.

Results

Ten RCTs were included. Probiotic supplementation significantly reduced HbA1c (WMD = -0.11; 95% CI: -0.18, -0.04; p < 0.001; I ² = 0.0%) and increased HDL-C (WMD: 2.37; 95% CI: 1.02, 3.71; p < 0.001; I²  = 0.0%). Moreover, there were no significant effects of probiotic supp

SUBMITTER: Liu R 

PROVIDER: S-EPMC12434957 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature