Evaluation of Interstitial Fluid Volume and Diffusivity in Patients With Idiopathic Normal Pressure Hydrocephalus Using Spectral Diffusion Analysis.

ABSTRACT:

Background

Changes in interstitial fluid (ISF) dynamics are potential contributors to idiopathic normal pressure hydrocephalus (iNPH). Spectral diffusion analysis provides surrogate markers for ISF volume (F _int) and diffusivity (D _int).

Purpose

To compare F _int and D _int between patients with iNPH and healthy controls (HCs).

Study type

Retrospective.

Population

34 patients with iNPH (24 males, 10 females; 76.9 ± 7.6 years) and 132 HCs (46 males, 86 females; 47.5 ± 16.9 years; three age groups: < 40 years, 40-59 years, and ≥ 60 years).

Field strength/sequence

3.0 T/Single-shot spin-echo echo-planar imaging.

Assessment

F _int and D _int were computed using non-negative least squares an

SUBMITTER: Ishida S 

PROVIDER: S-EPMC12435118 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature