Clinical Utility of Far-Field Potentials in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Introduction/aims

Far field potentials (FFP) have been proposed as a reliable neurophysiological prognostic biomarker in amyotrophic lateral sclerosis (ALS). This study evaluates the diagnostic utility of ulnar nerve FFP in ALS.

Methods

Comprehensive peripheral neurophysiological assessments were conducted in 62 ALS and 43 ALS-mimicking disorder participants. The ulnar nerve was stimulated at the wrist, recording motor responses over the abductor digit minimi (ADM) muscle. Conventional compound muscle action potentials (CMAP), FFP, and near field potential amplitudes were recorded, alongside the split-hand index, neurophysiological index, motor unit number estimation (MScanFit-MUNE), and motor unit index (MUNIX). Diagnostic utility was evaluated using receiver operating char

SUBMITTER: Calma AD 

PROVIDER: S-EPMC12435138 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature