Cognition-Eye-Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging.

ABSTRACT:

Background

The connection between cognition, eye, and brain remains inconclusive in Alzheimer's disease (AD) spectrum disorders.

Purpose

To explore the relationship between cognitive function, retinal biometrics, and brain alterations in the AD spectrum.

Study type

Prospective.

Subjects

Healthy control (HC) (n = 16), subjective cognitive decline (SCD) (n = 35), mild cognitive impairment (MCI) (n = 18), and AD group (n = 7).

Field strength/sequence

3-T, 3D T1-weighted Brain Volume (BRAVO) and resting-state functional MRI (fMRI).

Assessment

In all subgroups, cortical thickness was measured from BRAVO and segmented using the Desikan-Killiany-Tourville (DKT) atlas. The fractional amplitude of low-frequency fluctuations (FALFF) and regional homogeneity

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12435140 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature