Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted ^99mTc, ⁶⁴Cu and ¹⁸⁸Re radiotracers.

ABSTRACT: The diagnostic imaging radionuclide, ^99mTc, used in Single Photon Emission Computed Tomography (SPECT), has extraordinary potential for enabling economical molecular receptor imaging in oncology, provided suitable chelators are available to enable kit-based radiolabelling. We report the development of two new bis(phosphino)maleic anhydrides, DP^An and DP^MEP, that exhibit increased electron donor capacity and concomitant increased radiochemical yields compared to their first-generation diphosphine analogues. Both DP^An and DP^MEP can be reacted with a wide range of biological targeting vectors, including receptor-targeted peptides, carbohydrates, vitamins and small-molecule inhibitors. Exemplar diphosphine-peptide bioconjugates, DP^An<

SUBMITTER: Nuttall RE 

PROVIDER: S-EPMC12435366 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature