Phytochemical Investigation and Biological Evaluation of Disynaphia filifolia: A Novel Source of Tremetone in Asteraceae.

ABSTRACT: Chemical investigation of Disynaphia filifolia (Hassl.) R.M. King & H. Rob. (Asteraceae) led to the isolation of eight compounds, with tremetone being the major metabolite recovered. Tremetone has been suggested as the toxic compound in Ageratina altissima and Isocoma pluriflora, two species of the Asteraceae family. Although D. filifolia is not classified as a toxic species, tremetone was identified as the major compound in the crude extract of this species, constituting approximately 21% of the total content. Furthermore, 22 compounds were annotated using dereplication techniques, ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry, and a molecular networking approach. Antiproliferative assays indicated that tremetone was weakly active again

SUBMITTER: Chierici YR 

PROVIDER: S-EPMC12435406 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature