Copper Single-Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis.

ABSTRACT: Carbon-heteroatom cross-coupling reactions have become indispensable tools in synthetic chemistry. However, the formation of carbon-sulfur (C─S) bonds, which are essential for producing thioethers used in pharmaceuticals, agrochemicals, and advanced materials, remains significantly underdeveloped. Industrial C─S coupling methods still rely on expensive, homogeneous catalysts that suffer from poor recyclability and are susceptible to sulfur-induced deactivation. In this work, we report a copper single-atom catalyst, where Cu sites are atomically dispersed on mesoporous graphitic carbon nitride, to enable efficient, selective, and recyclable C─S cross-coupling reactions under mild conditions and on a gram scale. The catalyst exhibits excellent resistance to thiol poisoning and maintains high

SUBMITTER: Gazis TA 

PROVIDER: S-EPMC12435431 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature