Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of <i>Mycobacterium abscessus</i> lung disease.

ABSTRACT:

Background

Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT. However, a 1-h half-life means multiple infusions per day, which is difficult for months-long therapy.

Methods

As an alternative, we tested ceftaroline-avibactam, with a 3-h half-life, in the hollow-fibre model system of MAB-LD (HFS-MAB). Eight ceftaroline-avibactam exposures were administered twice daily based on human intrapulmonary pharmacokinetics. Next, we compared GBT (cefoxitin-clarithromycin-amikacin) to standard-dose and to high-dose ceftaroline-avibactam-tigecycline-moxifloxacin regimens, in the HFS-MAB, mimicking the intrapulmon

SUBMITTER: Ferro BE 

PROVIDER: S-EPMC12435454 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature