Earlier diagnosis of intrahepatic cholestasis of pregnancy and adverse pregnancy outcomes.

ABSTRACT:

Introduction

We aimed to determine whether pregnancies complicated by early diagnosis of cholestasis were associated with adverse maternal or neonatal outcomes.

Methods

This is a retrospective cohort study of singleton, non-anomalous live gestations complicated by cholestasis from 2005-2019. We compared rates of adverse outcomes in pregnancies complicated by early (<32-week gestational age) versus late (≥ 32-week gestational age) diagnosis of cholestasis. Our primary outcome of interest was rates of spontaneous preterm birth. Secondary outcomes included rates of iatrogenic preterm birth, meconium-stained amniotic fluid, cesarean delivery for non-reassuring fetal heart tracing, and neonatal intensive care unit admission.

Results

Of the 1247 pregnancies complicated by c

SUBMITTER: Sarker MR 

PROVIDER: S-EPMC12435465 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature