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Cobalt-catalyzed direct carbonylative 3-acylation of (N-H)Indoles with alkyl halides.

ABSTRACT: A cobalt-catalyzed approach to intermolecular carbonylative 3-acylation of heterocycles via C-H functionalization is described. This transformation enables the direct C-H acylation of indoles and pyrroles with alkyl halides. Notably, this procedure is also compatible with indoles containing unprotected NH groups. Overall, this methodology represents an atom-economical and general strategy for synthesizing alkyl-(hetero)aryl ketones.

SUBMITTER: Xu C 

PROVIDER: S-EPMC12435503 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed direct carbonylative 3-acylation of (N-H)Indoles with alkyl halides.

Xu Chao C   Bao Zhi-Peng ZP   Shao Sufang S   Wu Xiao-Feng XF  

Chemical science 20250905 40

A cobalt-catalyzed approach to intermolecular carbonylative 3-acylation of heterocycles <i>via</i> C-H functionalization is described. This transformation enables the direct C-H acylation of indoles and pyrroles with alkyl halides. Notably, this procedure is also compatible with indoles containing unprotected NH groups. Overall, this methodology represents an atom-economical and general strategy for synthesizing alkyl-(hetero)aryl ketones. ...[more]

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