Clinical, virological, and antibody profiles of overlapping dengue and chikungunya virus infections in children from southern Colombia.

ABSTRACT:

Background

Dengue and chikungunya are arboviral diseases with overlapping clinical characteristics. Dengue virus (DENV) is endemic in Colombia, and in 2014/2015, the chikungunya virus (CHIKV) caused an epidemic that resulted in over 350,000 cases. Since then, both viruses have been actively co-circulating. The early and accurate identification of pediatric infection caused by DENV or CHIKV is essential for proper medical management. Given that subsequent infections and co-infections with DENV and CHIKV have been reported, virological and immunological factors may influence their clinical outcomes. Here, we analyzed the viremia, antigenemia, and virus-specific antibody responses in hospitalized children suspected of having dengue during the peak of CHIKV infections in Colombia.

M

SUBMITTER: Polania-Espinosa D 

PROVIDER: S-EPMC12435647 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature