Study on the effect of modified Liu-an decoction on Th1/Th2 function in Guinea pigs with cough variant asthma through the Notch signal pathway.

ABSTRACT:

Objective

To explore the effects and mechanism of Modified Liu-an Decoction (MLAD) on Th1/Th2 function and the Notch signaling pathway in guinea pigs with cough variant asthma (CVA).

Methods

60 SPF Hartley guinea pigs were randomized into six groups (n = 10): the blank control group, model group, montelukast sodium group (MS group), as well as MLAD group of low-dose, mid-dose and high-dose. Intraperitoneal injection of ovalbumin, aluminum hydroxide sensitization, and nebulized inhalation of ovalbumin were performed in all guinea pigs of non-blank control groupto induce CVA. Cough frequency and airway resistance were recorded. The chronic inflammatory infiltration in the airways was detected by using HE and Masson staining smears. The IL-2, IL-4, IL-12, and IL-13 levels were

SUBMITTER: Xu F 

PROVIDER: S-EPMC12435660 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature