Disrupted cholesterol biosynthesis and hair follicle stem cell impairment in the onset of alopecia.

ABSTRACT:

Background

Hair follicle cycle and the functioning of stem cells in alopecia are influenced by the suppression of cholesterol synthesis and the accumulation of sterol intermediates.

Objective

This investigation aims to elucidate the regulatory function of disrupted cholesterol homeostasis in the functioning of hair follicle stem cells (HFSCs) and the cycling of hair follicles. Additionally, it seeks to provide an understanding of the fate of stem cells in primary cicatricial alopecia (PCA).

Methods

To evaluate the influence of cholesterol on the functionality of hair follicles, a study was conducted to analyse gene expression and pathways associated with hair follicle stem cell markers in scalp samples affected by PCA (LPP, FFA, CCCA, DC, DF, TF). To assess the influe

SUBMITTER: Nikhila L 

PROVIDER: S-EPMC12435693 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature