A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.

ABSTRACT: The CA3 region of the hippocampus is essential for associative memory. CA3 pyramidal neurons receive three canonical excitatory inputs-recurrent collaterals from other CA3 pyramidal neurons, mossy fiber input from the dentate gyrus (DG), and perforant path input from the entorhinal cortex-that terminate at specific dendritic compartments and have distinct functions. Yet, the additional extrahippocampal inputs to CA3 are less clear. Here, we report a monosynaptic glutamatergic input from the basolateral amygdala (BLA) that preferentially innervates ventral CA3. The CA3-projecting BLA neurons are topographically clustered in a small area near the medial border of BLA and preferentially innervate basal dendrites of distal CA3 (near CA1). Moreover, the BLA input preferentially excites regular-

SUBMITTER: Li M 

PROVIDER: S-EPMC12435738 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature