Caloric restriction promotes resolution of atherosclerosis in obese mice, while weight regain accelerates its progression.

ABSTRACT: While weight loss is highly recommended for those with obesity, >60% regain their lost weight. This weight cycling is associated with an elevated risk of cardiovascular disease, relative to never having lost weight. How weight loss and regain directly influence atherosclerotic inflammation is unknown. Thus, we studied short-term caloric restriction (stCR) in obese hypercholesterolemic mice, without confounding effects from changes in diet composition. Weight loss promoted atherosclerosis resolution independent of plasma cholesterol. Single-cell RNA sequencing and subsequent mechanistic studies indicated that this can be partly attributed to a unique subset of macrophages accumulating with stCR in epididymal white adipose tissue (eWAT) and atherosclerotic plaques. These macrophages, disting

SUBMITTER: Scolaro B 

PROVIDER: S-EPMC12435835 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature