Birth Weight, Cardiovascular Health, and Microvascular Complications in Individuals with Diabetes Mellitus.

ABSTRACT:

Backgruound

Diabetes often leads to microvascular complications, including nephropathy, neuropathy, and retinopathy. Understanding the impact of early-life factors like birth weight and modifiable behaviors such as cardiovascular health (CVH) is essential for preventing these complications.

Methods

We included 11,515 participants with diabetes but without microvascular complications at baseline from the UK Biobank Study. CVH was evaluated using the Life's Essential 8 score. Independent and joint associations of birth weight and CVH with microvascular complications were analyzed using Cox proportional hazard models. Two-sample Mendelian randomization (MR) analyses estimated unconfounded associations between birth weight and microvascular complications.

Results

Over a m

SUBMITTER: Yu C 

PROVIDER: S-EPMC12436046 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature