Development of a new alternative method to inhalation exposure: intratracheal instillation studies using molecular dispersion.

ABSTRACT:

Background

Organic chemicals have been known to cause allergic diseases such as bronchial asthma and hypersensitivity pneumonitis; however, the possibility that they do not cause irreversible pulmonary fibrosis has not been considered. Polyacrylic acid (PAA), an organic chemical, has caused irreversible progressive pulmonary fibrosis in exposed workers, indicating its potential to induce pulmonary inflammation and fibrosis. Although intratracheal instillation studies are commonly used for evaluating lung pathology, traditional methods face challenges with chemical substances, particularly nanoparticles, which tend to aggregate in suspension and prevent uniform pulmonary distribution. Such aggregation alters the qualitative and quantitative responses to lung injury, limiting accurat

SUBMITTER: Morimoto T 

PROVIDER: S-EPMC12436071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature