Lipid biomarkers of GVHD in allogeneic stem hematopoietic cell transplantation patients.

ABSTRACT:

Objective

While dyslipidemia is established as a key modulator of innate and adaptive immune responses, its role in hematopoietic reconstitution remains unclear. This study aimed to characterize lipid profiles in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and evaluate the associations between dyslipidemia and clinical outcomes.

Methods

A retrospective analysis was conducted in a cohort of 106 adult patients (≥18 years) who underwent allogeneic HSCT between January 2019 and December 2023 and had complete lipid records.

Results

Profound dyslipidemia was observed post-transplantation, with over 60% of patients developing significantly decreased high-density lipoprotein cholesterol (HDL-C) and elevated triglycerides (TG), total cholester

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12436127 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature