The biological and immunological significance of the estrogen-related gene IER3 in diabetes.

ABSTRACT:

Background

Diabetes Mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia, primarily arising from insufficient insulin secretion or the development of insulin resistance. Estrogen plays a significant role in regulating the occurrence and progression of DM. This study aims to investigate the role of estrogen-related genes in diabetes, focusing on identifying potential biomarkers and therapeutic targets for the disease.

Methods

We initially obtained gene expression datasets related to type 2 diabetes mellitus (T2DM) from the GEO database. A systematic and coherent series of methodologies was then implemented in a structured manner. First, Principal Component Analysis (PCA) was employed for preliminary data exploration and dimensionality reduction. Next,

SUBMITTER: Ke D 

PROVIDER: S-EPMC12436140 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature