The habenula in mood disorders: A systematic review of human studies.

ABSTRACT:

Background

In animal models, the habenula has been identified as a key structure involved in mood disorders (MDs). Thanks to recent technological advancements, a burgeoning body of work has also investigated the habenula in the context of human MDs.

Objective

This systematic review aims to synthesize findings from human studies concerning the habenula and its relationship with MDs. The review was conducted according to PRISMA guidelines. The literature search yielded 93 articles, of which 50 articles were included in the review.

Results

We found that the evidence for baseline habenular hyperactivity in human depression is mixed. Although the finding of baseline habenular hyperactivity is widely replicated in animal models of depression, the available evidence is not s

SUBMITTER: Fortin JS 

PROVIDER: S-EPMC12436162 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature