Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.

ABSTRACT: Peripartum depression can have severe impact on the mother's and the infant's health. Yet, its biological underpinnings are largely unknown. The present study sought to identify transcriptomic signatures of depressive symptoms during pregnancy and postpartum. Blood samples were collected during late pregnancy or early postpartum for mRNA isolation and sequencing, while depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Based on the timepoint when the samples were collected, differentially expressed genes (DEGs) were identified by (1) comparing mRNA levels between the depression symptom trajectory groups, and (2) correlating with EPDS scores. DEGs for samples collected during late pregnancy, but not postpartum, were associated with depressive symptoms o

SUBMITTER: Bjorvang RD 

PROVIDER: S-EPMC12436180 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature