Laboratory assessment of fetomaternal haemorrhage and Rh immune globulin management: Canadian practice and scoping review.

ABSTRACT: Fetomaternal haemorrhage (FMH) in RhD-negative individuals can lead to alloimmunization with future antibody-mediated destruction of fetal red blood cells. Accurate estimation of FMH is essential for guiding the dose of Rh immune globulin and mitigating alloimmunization. We conducted a national survey and performed a scoping review to determine the availability, technical characteristics and clinical limitations of FMH tests. We describe the evolution of FMH testing, including the qualitative methods (alpha-fetoprotein level, microscopic weak D test, enzyme-linked antiglobulin test, rosette test, gel agglutination cards) and the quantitative methods (Kleihauer-Betke test, flow cytometry assays). Although the rosette test is the most commonly used qualitative method, it may yield false-nega

SUBMITTER: Hajjaj OI 

PROVIDER: S-EPMC12436229 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature