Autologous haematopoietic stem cell transplantation for multiple sclerosis in the UK: A 20-year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT).

ABSTRACT: Autologous haematopoietic stem cell transplantation (AHSCT) has been developed as a treatment for multiple sclerosis (MS) since 1995. The United Kingdom is one of the most active countries performing AHSCT for MS in Europe. We report the UK experience of AHSCT for MS in 364 patients with MS treated with AHSCT between 2002 and 2023. We report transplant-related mortality (TRM), AHSCT complications and efficacy as defined by expanded disability status scale (EDSS) progression-free survival (PFS) at 2 years and 5 years. 209 (58%) had relapsing-remitting MS (RRMS) and 130 (36%) had progressive MS. Median EDSS at the time of HSCT was 6.0 (range: 0-9) and duration of disease was 10 years (range: 4-34). TRM was 1.4%, exclusively occurred in patients with advanced baseline disability (median EDSS:

SUBMITTER: Kazmi M 

PROVIDER: S-EPMC12436235 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature