Development of a 'green' wound healing hydrogel rich in apigenin-7-O-glucoside using an ultrasonication-assisted solvent extract of tomatoes.

ABSTRACT: The study focuses on ultrasonication-assisted green solvent extraction of apigenin-7-o-glucoside from whole tomatoes (Solanum lycopersicum) and subsequent formulation of a novel hydrogel for epidermal wound healing. Optimisation of extraction parameters was performed using Box-Behnken design of experiments and predictive modelling by response surface methodology (RSM) as well as artificial neural network (ANN). HPTLC analysis confirmed a yield of 12.08 µg of apigenin-7-o-glucoside/g tomatoes (dwb) in the extract under the optimised extraction conditions (ethanol:water 1:1 ratio, 60 min, 55 °C). The presence of the same in highest abundance was validated by ESI-TOF-MS analysis of the extract. The ANN-based multilayer perceptron model (3-8-1 architecture) exhibited superior pre

SUBMITTER: Kundu D 

PROVIDER: S-EPMC12436250 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature