The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways.

ABSTRACT:

Background

Exosomes play a critical role in the tumor microenvironment by interacting with signaling pathways that facilitate breast cancer metastasis, particularly the STAT3 pathway. The STAT3 pathway is essential for tumor progression and aggressiveness, as it interacts with other pathways like Wnt and Notch in particular, triple-negative breast cancer (TNBC) which is the most aggressive form of breast cancer, with a poor prognosis and rapid metastasis. It is exciting to researchers because it is therapeutically challenging and highly invasive. As a result of the lack of specific treatment options, conventional therapy is widely used, which frequently results in relapse.

Objectives

Elucidate the critical roles of exosomes in modulating breast cancer behaviour and disease p

SUBMITTER: Mohamed SA 

PROVIDER: S-EPMC12436252 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature