Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice.

ABSTRACT:

Introduction

Painful diabetic peripheral neuropathy (PDPN) is closely linked to cognitive dysfunction. The gut microbiota plays a pivotal role in the pathophysiology of diabetic neuropathy, but its contribution, along with related metabolites, to PDPN complicated by cognitive impairment remains poorly understood. This study aimed to explore the characteristics of gut microbiota and metabolites in db/db mice with PDPN and concomitant cognitive impairment, and to investigate the underlying mechanisms.

Methods

Male homozygous db/db mice and their littermate db/m mice used as the research subjects. Thermal hyperalgesia and mechanical allodynia tests were applied to assess pain phenotypes, while the Morris water maze test was used to eval

SUBMITTER: Yang J 

PROVIDER: S-EPMC12436300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature