Harnessing outer membrane vesicles derived from <i>Bordetella pertussis</i> to overcome key limitations of acellular pertussis vaccines.

ABSTRACT: Acellular pertussis (aP) vaccines have markedly reduced the global burden of severe pertussis. However, their limited ability to elicit mucosal and durable immunity has been linked to waning protection and sustained Bordetella pertussis circulation. Selective pressure exerted by widespread aP vaccination has contributed to the emergence and regional dissemination of pertactin-deficient (PRN^-) strains, raising additional concerns regarding vaccine effectiveness. In this context, we investigated whether incorporating outer membrane vesicles (OMVs) derived from B. pertussis into the aP vaccine could enhance its immunological profile, specifically by promoting Th1/Th17 polarization, inducing tissue-resident memory (TRM) T cells, and broadening protective coverage to in

SUBMITTER: Locati L 

PROVIDER: S-EPMC12436301 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature