Gut microbiome modulation by Weifuchun Capsules alleviates chronic atrophic gastritis: a combined microbiota and metabolomics approach.

ABSTRACT:

Background

Weifuchun Capsule (WFC), a traditional Chinese medicinal formula containing Panax ginseng (red ginseng), Rabdosia rubescens, and Fructus Aurantii, is widely used clinically for the management of chronic atrophic gastritis (CAG). Although previous clinical evidence has demonstrated the efficacy of WFC in alleviating symptoms and improving gastric mucosal health, the precise mechanisms, particularly those mediated by gut microbiota, remain poorly understood. Given the crucial role of intestinal microbial dysbiosis in gastrointestinal disorders, exploring the microbiota-dependent pharmacological mechanisms of WFC is essential for understanding its therapeutic benefits in CAG.

Methods

We established a rat model of CAG to investigate the microbiota

SUBMITTER: Xie W 

PROVIDER: S-EPMC12436308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature