Study of the cervical canal microbiome and microbiocenosis in reproductive-age women with squamous intraepithelial lesion.

ABSTRACT:

Introduction

The study of the cervicovaginal microbiome is a critical area of research in medical science. According to scientific data, microorganisms inhabiting the lower female genital tract may influence susceptibility to and persistence of human papillomavirus (HPV), as well as the development and progression of squamous intraepithelial lesions (SIL) toward cervical cancer (CC).

Methods

The study included 67 patients with a histological diagnosis of low-grade squamous intraepithelial lesion (LSIL) and 85 patients with high-grade squamous intraepithelial lesion (HSIL). The cervical canal microbiome of patients with LSIL (n = 31) and HSIL (n = 45) was examined using the 16S rRNA gene sequencing method, while the microbiocenosis of the remaining patients with

SUBMITTER: Peremykina A 

PROVIDER: S-EPMC12436378 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature