Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.

ABSTRACT: Hyperuricemia is a key risk factor for chronic kidney disease (CKD), yet effective treatments remain limited. This study demonstrates that quercetin exerts potent renoprotective effects in hyperuricemia-induced CKD through multifaceted mechanisms. In rats with hyperuricemia induced by adenine (0.1 g/kg) and potassium oxonate (1.5 g/kg), quercetin treatment (50 or 100 mg/kg) significantly improved renal function by reducing urinary ACR, serum creatinine, uric acid, BUN, and blood pressure, while alleviating renal inflammation, fibrosis, and crystal deposition. Mechanistic studies revealed quercetin's ability to suppress ER stress markers (GRP78, CHOP, p-PERK, IRE1α, ATF6), inhibit renal GLUT9 expression, and downregulate downstream inflammatory (TLR4/NF-κB/IL-1β/TNF-α), fibrotic (collagen I

SUBMITTER: Liu H 

PROVIDER: S-EPMC12436389 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature