Association between inflammatory markers (SII and SIRI) and anxiety levels in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative disorder frequently associated with anxiety, which can significantly impair patients' quality of life. Emerging evidence suggests that systemic inflammation may contribute to the development of anxiety in PD. The Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) are composite biomarkers reflecting systemic inflammatory status. However, the relationship between these inflammatory markers and anxiety levels in PD patients remains to be elucidated.

Objective

To investigate the association between SII and SIRI and anxiety levels in PD patients.

Methods

This cross-sectional study utilized data from the PPMI database, including 1,289 PD patients. Anxiety levels were

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12436417 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature