Integrating scRNA-seq and GWAS data reveals potentially critical endothelial cells in large artery atherosclerotic stroke.

ABSTRACT:

Introduction

Stroke is a devastating cerebrovascular disease with limited treatment options. Structural and functional abnormalities in the cerebral vasculature contribute significantly to the development of stroke. Specifically, the blood-brain barrier formed by a combination of endothelial cells, smooth muscle cells, pericytes, and glial cells is proposed to play a critical role in stroke pathogenesis. However, the primary causative cell types in stroke are not well-defined.

Methods

Here we integrated single-cell RNA-sequencing data from cerebrovascular zonation structures with genome-wide association study (GWAS) data of various types of strokes to analyze stroke risk SNP loci enrichment in various cell types through heritability partitioning. Fourteen vascular cell clust

SUBMITTER: Deng H 

PROVIDER: S-EPMC12436452 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature