Prognostic value of metal-based ferroptosis and cuproptosis genes and score in lower grade gliomas.

ABSTRACT:

Background

Ferroptosis and Cuproptosis are newly defined forms of cell death. Despite distinct mechanisms, both involve metabolic processes in the TCA cycle and downstream pathways, crucial for anticancer immunity.

Methods

We evaluated Iron (Fe) and Copper-induced cell death in lower-grade gliomas (LGG) using The Cancer Genome Atlas (TCGA) data by developing a metal-based ferroptosis and cuproptosis genes score (MBFCGs) risk model. Lasso regression and survival analyses assessed MBFCGs' significance. An MBFCGs-based nomogram was created and its predictive performance verified. Signaling pathways, immune checkpoints, chemokines, and therapeutic response indicators were quantified using R/oncoPredict and Tidepay. Immunohistochemistry (IHC) examined candidate gene expression.

SUBMITTER: Saddozai UAK 

PROVIDER: S-EPMC12436455 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature