Berberine and its nanoformulations and extracts: potential strategies and future perspectives against multi-drug resistant bacterial infections.

ABSTRACT: The increasing prevalence of antimicrobial resistance (AMR) has led to the gradual decline in the effectiveness of existing antibiotics, posing a significant threat to global health. Many phytochemicals have antimicrobial activity, but few have been developed for clinical use. Berberine, an alkaloid found in various medicinal plants, has been recognized as a promising strategy to combat AMR due to its notable antimicrobial activity and role in reversing resistance. Here, we present a systematic, comprehensive and objective overview of the antimicrobial activity, mechanism of action, and limitations of berberine. Additionally, we discuss the antimicrobial efficacy of berberine extracts and nanoformulations. Berberine demonstrates broad-spectrum antimicrobial activity by inhibiting FtsZ, dis

SUBMITTER: Yang X 

PROVIDER: S-EPMC12436466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature