Neurofunctional correlates of emotional dysregulation in adolescent Crohn's disease: a resting-state fMRI preliminary investigation.

ABSTRACT:

Background

This study aimed to characterize the relationship between abnormal intrinsic brain function with emotional symptoms in adolescent Crohn's disease (CD) patients through resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

Forty adolescent CD patient and 53 healthy controls (HCs) were recruited and completed standardized assessments including the Inflammatory Bowel Disease Questionnaire (IBDQ), Symptom Checklist-90 (SCL-90), Social Support Rating Scale (SSRS), and rs-fMRI scans. Compared the intrinsic brain function between groups using amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF). Subsequent correlation analyses examined relationships between neuroimaging findings clinical indicators, and psychometric measures.

Res

SUBMITTER: Liu A 

PROVIDER: S-EPMC12436501 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature