Age at menarche and depression: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Age at menarche may influence the onset of depression later in life. We aim to assess the association between early/late menarche and depressive outcomes in females by updating a systematic review and meta-analysis.

Methods

The search of the original systematic review was updated for studies published in PubMed, Embase, and Cochrane Library from 2013 to 2023. The early/late and on-time menarche divisions were generally based on each study. Depression or depressive symptoms could be measured through various validated tools and diagnostic criteria. We assessed the quality of the evidence using the GRADE approach and performed a random-effect meta-analysis with age at menarche and the cases of depression as outcomes.

Results

We included eight cohort and three

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12436512 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature