Genotype distribution and molecular characterization of HPV in the Peruvian amazon: insights into prevalence, lineage diversity, and viral integration.

ABSTRACT: Cervical cancer remains a leading cause of cancer-related mortality among women in Peru, with the highest death rates reported in the Amazon region. Despite this burden, molecular data on human papillomavirus (HPV) in this area are limited. This study aimed to assess HPV genotype distribution and molecular characteristics in women undergoing cervical screening in the Peruvian Amazon. Between May and November 2024, cervical samples were collected from 503 women aged 25-55, along with an additional subset of 35 women with histologically confirmed CIN2 + lesions. HPV genotyping was performed using the Allplex™ HPV28 assay, and single infections with HPV16 or HPV52 were further analyzed by TaME-seq to determine lineage, intrahost variability, and integration. HPV prevalence was 51.7% (278/538)

SUBMITTER: Solis-Ponce L 

PROVIDER: S-EPMC12436591 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature