Performance of ¹²³I-ioflupane SPECT striatal binding in dementia with Lewy bodies.

ABSTRACT:

Introduction

We aimed to determine whether ¹²³I-ioflupane single-photon emission computed tomography (SPECT) striatal binding ratio (SBR) correlated with parkinsonian motor symptoms in dementia with Lewy bodies (DLB) and if SBR predicts worsening of parkinsonism over time.

Methods

A retrospective cohort study of the U.S. Dementia with Lewy Bodies Consortium dataset including individuals with DLB with baseline ¹²³I-ioflupane SPECT analyzed with DaTQUANT and baseline and 24-month Movement Disorder Society Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III). A subset had cerebrospinal fluid α-synuclein seed amplification assay (SAA) evaluation.

Results

Baseline mean SBRs were significant predictors of baseline and 24-month MDS-UPDRS-II

SUBMITTER: Maly EF 

PROVIDER: S-EPMC12438451 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature