Chronic pain in mental disorders: An umbrella review of the prevalence, risk factors, and treatments across 957,168 people with mental disorders and 16,606,910 controls.

ABSTRACT:

Background

Chronic pain (CP) and mental disorders often coexist, yet their relationship lacks comprehensive synthesis. This first hierarchical umbrella review examined systematic reviews and meta-analyses, also observational studies and randomized controlled trials (where reviews are currently lacking) to report CP prevalence, risk factors, and treatment across mental disorders.

Methods

We searched MEDLINE, PsycINFO, Embase, Web of Science, and CINAHL, identifying 20 studies on anxiety, depression, bipolar disorder, schizophrenia, ADHD, autism, or dementia, and CP. Quality was assessed using AMSTAR and Newcastle-Ottawa Scale.

Results

Prevalence varied widely-23.7% (95% CI 13.1-36.3) in bipolar disorder to 96% in PTSD-consistently exceeding general population rates (20

SUBMITTER: Stubbs B 

PROVIDER: S-EPMC12438992 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature