Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort.

ABSTRACT:

Introduction

Type 2 diabetes (T2D) is closely associated with excess adiposity, particularly visceral fat. The body roundness index (BRI), calculated from height and waist circumference, provides a refined estimate of visceral adiposity. This study aimed to investigate the associations of baseline BRI and longitudinal changes in BRI with the risk of incident T2D.

Research design and methods

We used UK Biobank data, a cohort involving adults aged 37-73 years. Both baseline and last follow-up BRI values were classified according to the tertiles of baseline BRI, and long-term BRI changes were categorized by baseline and follow-up grades. The annual average rate of change (AARC) of BRI was also calculated. Cox regression models were employed to evaluate HRs and 95% CIs, while re

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12439138 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature