Association of stress-induced autonomic dysfunction with heart failure in individuals with stable coronary artery disease.

ABSTRACT:

Background

Heart failure (HF) is a common complication in individuals with coronary artery disease (CAD). Autonomic effects of psychological stress may play an important, under-recognized role in this relationship. We hypothesized that stress-induced autonomic dysfunction, measured by change in low-frequency heart rate variability (HRV) during mental stress challenge, associates with increased HF risk.

Methods

We examined 662 participants with stable CAD and no known diagnosis of HF who underwent mental stress challenge via a standardized speaking task in conjunction with Holter monitoring. We evaluated HRV in 5-minute windows and examined its change from rest to stress as our primary exposure. Repeated events Cox proportional hazard models were used to examine incident and

SUBMITTER: Wang M 

PROVIDER: S-EPMC12439159 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature